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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ROCK2
All Species:
15.15
Human Site:
S493
Identified Species:
27.78
UniProt:
O75116
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75116
NP_004841.2
1388
160900
S493
E
E
I
T
L
R
K
S
V
E
S
A
L
R
Q
Chimpanzee
Pan troglodytes
P61584
1003
117506
Y252
K
S
Q
T
D
K
D
Y
Y
Q
L
Q
A
I
L
Rhesus Macaque
Macaca mulatta
XP_001096931
1524
173861
S629
E
E
I
T
L
R
K
S
V
E
S
A
L
R
Q
Dog
Lupus familis
XP_540083
1519
175559
N624
E
E
I
T
L
R
K
N
V
E
S
A
L
R
Q
Cat
Felis silvestris
Mouse
Mus musculus
P70336
1388
160567
S493
E
E
I
T
L
R
K
S
V
E
S
T
L
R
Q
Rat
Rattus norvegicus
Q62868
1379
159417
N484
E
E
I
T
F
R
K
N
V
E
S
T
L
R
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505615
1400
161955
A443
R
Q
L
D
E
A
N
A
L
L
R
T
E
S
D
Chicken
Gallus gallus
XP_419954
1438
166280
N543
E
E
I
T
S
R
K
N
V
E
S
A
V
R
Q
Frog
Xenopus laevis
NP_001154860
1372
159002
S479
E
E
A
K
A
R
K
S
I
E
S
T
T
R
Q
Zebra Danio
Brachydanio rerio
NP_777288
1375
159755
G479
E
E
M
N
S
R
K
G
L
E
S
T
L
R
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9W1B0
1637
186706
T508
E
V
F
E
R
L
K
T
Q
D
S
E
L
Q
D
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P92199
1173
135756
Q421
G
I
E
Q
H
K
P
Q
T
V
V
E
Q
P
L
Sea Urchin
Strong. purpuratus
XP_001198244
1323
154677
H449
L
E
N
N
D
K
L
H
L
Q
N
K
L
M
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
43.3
90.4
87.8
N.A.
96.6
95.7
N.A.
82.3
86.8
82
75.2
N.A.
24.1
N.A.
34.2
47.4
Protein Similarity:
100
56.9
90.8
89.5
N.A.
98.3
97.4
N.A.
86.2
91.9
89.9
86.6
N.A.
45.2
N.A.
52.8
64.9
P-Site Identity:
100
6.6
100
93.3
N.A.
93.3
80
N.A.
0
80
60
60
N.A.
26.6
N.A.
0
13.3
P-Site Similarity:
100
26.6
100
100
N.A.
93.3
86.6
N.A.
26.6
93.3
66.6
73.3
N.A.
46.6
N.A.
6.6
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
0
8
8
0
8
0
0
0
31
8
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
8
16
0
8
0
0
8
0
0
0
0
24
% D
% Glu:
70
70
8
8
8
0
0
0
0
62
0
16
8
0
0
% E
% Phe:
0
0
8
0
8
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
8
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
8
0
0
8
0
0
0
0
0
0
0
% H
% Ile:
0
8
47
0
0
0
0
0
8
0
0
0
0
8
0
% I
% Lys:
8
0
0
8
0
24
70
0
0
0
0
8
0
0
0
% K
% Leu:
8
0
8
0
31
8
8
0
24
8
8
0
62
0
16
% L
% Met:
0
0
8
0
0
0
0
0
0
0
0
0
0
8
0
% M
% Asn:
0
0
8
16
0
0
8
24
0
0
8
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
8
0
0
0
0
0
0
8
0
% P
% Gln:
0
8
8
8
0
0
0
8
8
16
0
8
8
8
62
% Q
% Arg:
8
0
0
0
8
62
0
0
0
0
8
0
0
62
0
% R
% Ser:
0
8
0
0
16
0
0
31
0
0
70
0
0
8
0
% S
% Thr:
0
0
0
54
0
0
0
8
8
0
0
39
8
0
0
% T
% Val:
0
8
0
0
0
0
0
0
47
8
8
0
8
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
8
8
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _